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Despite its original purpose, letrozole has shown a lot of promise as a fertility medication. Increases in pregnancy rates were observed in both individual studies and meta-analyses, however, the higher pregnancy rates with femara were not statistically significant. That is, there is a trend toward a larger chance of pregnancy with femara than clomid, but that trend isn’t strong enough to argue that it is a sure thing. Hi! so i had 3 cycles of clomid, 50mg twice then last cycle 100mg as wasn't ovulating soon enough - got bfp last cycle but mmc sadly. Because i still ovualted late after mmc i got moved to letrozole 5mg cd2-cd6 and ovulated cd16 (first time in my life - i'm 34, have long cycles w/pcos and ttc years) - we got our bfp 9dpo! Canadian and u. Obstetric society guidelines were updated in 2018 to list letrozole as first-line medical therapy for women with anovulatory pcos who are trying to conceive. Letrozole has also been used to treat endometriosis. Endometrial stromal sarcomas are hormonally sensitive tumors as it is represented that letrozole reduces serum estrogen levels,letrozole is well tolerated and is a good option for long-term management of this disease. Letrozole and clomid are both used for ovulation induction, but they have different mechanisms of action. Letrozole has been shown to be superior to clomid in achieving live birth rates in women with infertility and polycystic ovary syndrome. However, the combination of these medications has not been studied. For an average patient, iui paired with letrozole or clomid delivers the best mix of decent birth rates with limited risks of multiple gestations. But, if you don’t ovulate using clomid or letrozole, or if you have hypothalamic dysfunction, then gonadotropins are necessary. For women with pcos, letrozole is superior to clomid. Clomid citrate acts by stimulating production of fsh and lh from the pituitary gland. Letrozole acts at the level of the ovaries to stimulated pituitary production of fsh and lh as well. Gonadotropins (fsh) act directly on the ovaries – these preparations are follicle stimulating hormone (fsh) and/or luteinizing hormone (lh). Fertility drugs – femara vs. Femara – generic brand letrozole – is an oral fertility medication commonly prescribed as an infertility treatment for women experiencing ovulation problems and/or unexplained infertility. Although femara’s original purpose was to treat breast cancer, presently it is a drug included. Answer: the purpose of letrozole is to control estrogen levels, with the typical goal being the low end of normal. Tamoxifen ( nolvadex ) and clomiphene ( clomid ) and the serms in general don’t control estrogen levels but do, in some tissues, block the action of estrogen. Cd2-6 took clomid 100mg at noon and letrozole 7. 5mg at bedtime cd14 had a transvaginal ultrasound showing only one decent sized 15mm follicle on the left ovary (where i had been having some discomfort) 
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